The Portuguese made six changes for Thursday's 2-0 victory over Zorya Luhansk in the Europa League, but has reverted back to the team which drew 1-1 with Everton for the clash with Mauricio Pochettino's side.
That means there is no place for either Wayne Rooney, who returns from a domestic suspension, nor Eric Bailly, who played in Odessa in midweek following almost seven weeks out with a knee injury.
Henrikh Mkhitaryan starts for a fourth successive fixture after a string of impressive showings which have seen him become more regularly involved in the United setup.
For the visitors, Toby Alderweireld is back in the starting lineup for the first time since suffering a knee injury in October against West Bromwich Albion, while Harry Kane leads the line against a club he was often linked with before signing a recent new deal at White Hart Lane which will keep him in north London until 2022.
Man Utd: De Gea, Valencia, Jones, Rojo, Darmian, Carrick, Herrera, Mkhitaryan, Pogba, Martial, Ibrahimovic. Subs: Romero, Bailly, Mata, Blind, Rashford, Rooney, Fellaini.
Tottenham: Lloris; Walker, Alderweireld, Vertonghen, Rose; Wanyama, Dembele; Eriksen, Dele, Son; Kane. Subs: Vorm, Nkoudou, Dier, Sissoko, Wimmer, Winks, Davies.