Los Blancos are tied with Barcelona atop the table entering the match, which serves as Madrid's game in hand ahead of this weekend's final round of fixtures.
And Zidane hasn't taken any risks for the mid-week match, with right-back Danilo the only choice that could be seen as a surprise.
The full-back is selected ahead of Nacho despite the Spaniard having his yellow card against Sevilla rescinded which would have seen him suspended.
James Rodriguez misses out after he picked up a knock earlier in the week.
Real Madrid: Navas; Danilo, Ramos, Varane, Marcelo; Modric, Casemiro, Kroos; Isco, Benzema, Ronaldo. Subs: Casilla, Nacho, Coentrao, Kovacic, Lucas Vazquez, Asensio, Morata