Andre Gomes starts for Barcelona in El Clasico, with Andres Iniesta only fit enough to make the bench.
The hosts names the same side as the one that drew 1-1 with Real Sociedad last time out with Lionel Messi captaining the club for the first time in a Clasico clash
Real Madrid, meanwhile, make four changes with Isco given the nod ahead of James Rodriguez for Real Madrid.
Dani Carvajal, Raphael Varane and Marcelo also come in with Danilo, Pepe and Nacho the men to make way.
Barcelona XI: Ter Stegen; Roberto, Pique, Mascherano, Alba; Rakitic, Busquets, Andre Gomes; Suarez, Messi, Neymar.
Subs: Cillessen, Denis, Arda, Iniesta, Alcacer, Digne, Umtiti.
Real Madrid XI: Navas; Carvajal, Ramos, Varane, Marcelo; Modric, Kovacic, Isco; Vazquez, Benzema, Ronaldo.
Subs: Casilla, Pepe, Nacho, James, Casemiro, Mariano, Asensio