Mauricio Pochettino is yet to add to his squad this summer and will be without a number of his players due to their participation at the World Cup.
Roma, on the other hand, will have the opportunity to field a number of new faces.
The Serie A side have sculpted a squad which they hope can challenge Juvenus in the fight for the Italian title and Wednesday will be the very beginning of that charge.
|Game||Roma vs Tottenham|
|Date||Wednesday, July 25|
|Time||3:05am BST / 7:05pm ET|
TV Channel, Live Stream & How To Watch
In the United States (US) the game will be shown live on television on ESPN and will be available to stream live online via WatchESPN.
|US TV channel||Online stream|
In the United Kingdom (UK), the game can be watched live on TV via Premier Sports and streamed on the Premier Player app.
|UK TV channel||Online stream|
|Premier Sports||Premier Player|
Squads & Team News
|Goalkeepers||Mirante, Fuzato, Cardinali|
|Defenders||Karsdorp, Pellegrini, Jesus, Kolarov, Marcano, Santon, Fazio, Florenzi, Manolas, Bianda|
|Midfielders||Cristante, Strootman, Pellegrini, De Rossi, Coric, Gonalons, Pastore|
|Forwards||Perotti, Dzeko, Schick, Under, Defrel, Kluivert, El Shaarawy|
Roma will be without goalkeeper Alisson Becker for their meeting with Tottenham following the Brazilian's record-breaking transfer to Liverpool.
Summer signing Justin Kluivert may be involved, however, with Javier Pastore set to make another outing after the club's 9-0 friendly win over Latina and 1-1 draw with Avellino.
Potential Roma XI: Mirante; Karsdorp, Manolas, Juan, Kolarov; Gonalons, Cristante, Pastore; Kluivert, Schick, Dzeko.
|Goalkeepers||Austin, Gazzaniga, Vorm, Whiteman|
|Defenders||Aurier, Carter-Vickers, Davies, Eyoma, Sanchez, Walker-Peters|
|Midfielders||Eriksen, Georgiou, Marsh, Lucas, N'Koudou, Oakley-Boothe, Sissoko, Skipp, Wanyama|
|Forwards||Lamela, Llorente, Son|
Given the heavy Tottenham contingent representing their countries in Russia, Pochettino is likely to name a youthful Spurs team against Roma.
World Cup winner Hugo Lloris has been handed an extended break, as has Harry Kane, Dele Alli and Jan Vertonghen.
Potential Tottenham XI: Vorm; Aurier, Sanchez, Foyth, Davies; Oakley-Boothe, Wanyama, Son, Lamela, Lucas; Llorente
Betting & Match Odds
Roma are considered to be favourites to win the game, with dabblebet offering odds of 6/5 on the Serie A side coming out on top. Spurs are priced at 2/1 and a draw is available at 13/5.
Tottenham will be without nine first-team players for Wednesday's tie, allowing a number of squad players to make a mark ahead of the new Premier League season.
"It's a massive opportunity for our younger players to show their quality and for players to show they are in condition to fight for a place in the first team," Pochettino told the official Spurs website.
"We're looking forward to playing, looking forward to a nice tour and sharing time with our fans, that's important too.
"We have three very good tests and more than results, it's about how we are going to approach the games and both collective and individual performances."
Roma and Spurs met in last year's ICC tournament, with the Italian side running out 3-2 winners in New York.
Tottenham will be looking to take revenge for last year's last-minute defeat, in which Diego Perotti scored an injury-time winner to sink the London club.