Both nations are in need of a morale-boosting win following a string of disappointing results and the match in Dublin promises to be a hard-fought contest.
Despite winning just one of their last nine matches, Martin O'Neill's men are available at 11/10 (2.10) with William Hill to claim bragging rights with victory against their northerly neighbours.
Michael O'Neill's outfit have failed to score in each of their last six matches away from Windsor Park and William Hill go 11/4 (3.75) that the Green and White Army claim a famous victory in Dublin.
The draw is chalked up as an 21/10 (3.10) chance with William Hill ahead of Thursday's tussle.
Robbie Brady and Seamus Coleman are back in the Republic squad, but Shane Long is out after picking up an ankle knock in training for Southampton last week. Aston Villa's Glenn Whelan will captain the home side in what is expected to be his final international appearance.
Kyle Lafferty is back in contention for the visitors after apologising for his his controversial late withdrawal from the Northern Ireland squad for last month's Nations League games. Niall McGinn, Gareth McAuley and Jamie Ward are all back for the match in Dublin.
Goals at a premium?
Somewhat surprisingly, there have been goals at both ends in just two of the previous 10 meetings between these rivals.
William Hill go 4/6 (1.67) that either side fails to find the net on this occasion, while the same firm go 1/2 (1.50) that there are fewer than three goals - that particular play would have landed in 11 of Northern Ireland's last 13 away matches.
With both teams seemingly bereft of belief, this is unlikely to be a classic encounter and the 13/8 (2.63) quote from William Hill for fewer than two goals to be scored could prove popular with punters ahead of Thursday's tussle.