Pep Guardiola's men outclassed the Blues and kept their unbeaten record intact at Stamford Bridge thanks to Kevin De Bruyne's second-half goal.
Goal has your complete guide to the latest set of fixtures, including the updated table.
PREMIER LEAGUE FIXTURES
|Sep 30||Huddersfield Town 0-4 Tottenham||12:30||Sky|
|Sep 30||Bournemouth 0-0 Leicester City||15:00||None|
|Sep 30||West Brom 2-2 Watford||15:00||None|
|Sep 30||West Ham 1-0 Swansea City||15:00||None|
|Sep 30||Stoke City 2-1 Southampton||15:00||None|
|Sep 30||Manchester United 4-0 Crystal Palace||15:00||None|
|Sep 30||Chelsea 0-1 Manchester City||17:30||BT|
|Oct 1||Arsenal 2-0 Brighton||12:00||BT|
|Oct 1||Everton 0-1 Burnley||14:15||Sky|
|Oct 1||Newcastle United 1-1 Liverpool||16:30||Sky|
Harry Kane had his scoring boots on once again, finding the target twice, as Tottenham thrashed Huddersfield Town 4-0 at lunchtime on Saturday. Ben Davies and Moussa Sissoko also netted for Spurs.
Five 15:00 fixtures then followed, with Manchester United also winning 4-0 thanks to two Marouane Fellaini goals against Crystal Palace. Juan Mata and Romelu Lukaku were also on the scoresheet.
High-flying Watford held West Brom to a 2-2 draw away from home thanks to Richarlison's 95th-minute equaliser but there was less drama at Bournemouth, who drew 0-0 with Leicester City.
West Ham recorded a much-needed 1-0 win at home against Swansea City and Stoke City were 2-1 victors over Southampton.
In the evening kick-off, De Bruyne's precise strike from 20 yards ensured City's fine performance at Chelsea was rewarded with three points.
On Sunday, Arsenal climbed into the top five with a 2-0 home victory against Brighton to get things started.
Everton's early-season woes continued as they were downed by Burnley in a north-west match-up before the action closed with Rafa Benitez holding his former employers to a point, as Newcastle drew 1-1 with Liverpool.
PREMIER LEAGUE TABLE
PREMIER LEAGUE TV COVERAGE
In the UK, Premier League games will be available to watch live on Sky Sports and BT Sport, with the BBC broadcasting highlights on Match of the Day. Viewers will also be able to stream games live online using Sky Go and the BT Sport app.
|UK TV channel||UK online stream|
|Sky Sports / BT Sport||Sky Go / BT Sport app|
In the U.S., up to 250 Premier League games will be available to watch live on television on NBC's various channels, including NBC, NBCSN and CNBC. These games can be streamed on NBC Sports Live.
The network also announced in June that a further 130 games would be exclusively available with the 'Premier League Pass' on NBC Sports Gold. The 'Premier League Pass' service will cost $50.
|US TV channel||US online stream|
|NBC Sports||NBC Sports Live|
LAST WEEKEND'S RESULTS
|Sep 23||West Ham 2-3 Tottenham||12:30||Sky|
|Sep 23||Burnley 0-0 Huddersfield Town||15:00||None|
|Sep 23||Everton 2-1 Bournemouth||15:00||None|
|Sep 23||Manchester City 5-0 Crystal Palace||15:00||None|
|Sep 23||Southampton 0-1 Manchester United||15:00||None|
|Sep 23||Swansea City 1-2 Watford||15:00||None|
|Sep 23||Stoke City 0-4 Chelsea||15:00||None|
|Sep 23||Leicester City 2-3 Liverpool||17:30||BT|
|Sep 24||Brighton 1-0 Newcastle||16:00||Sky|
|Sep 25||Arsenal 2-0 West Brom||20:00||Sky|
The early kick-off last weekend was at the London Stadium, where Tottenham raced into a 3-0 lead in the second half.
West Ham pulled one back before Serge Aurier was sent off, though, and Cheikhou Kouyate's second made it a very nervy finish for Spurs, who just about held out for three points.
Later on, Manchester United earned a 1-0 victory at Southampton despite withstanding late pressure thanks to Romelu Lukaku's sixth league goal of the season.
Defending champions Chelsea were more convincing winners, with Alvaro Morata's hat-trick driving them to a 4-0 victory at Stoke City - as were Manchester City, who won 5-0 on the back of four second-half goals against Crystal Palace.
Surprise packages Burnley and Huddersfield Town played out a 0-0 draw at Turf Moor but there was more drama at Swansea City and Everton.
Watford emerged 2-1 winners in Wales thanks to Richarlison's late winner, while the Toffees earned three points by the same scoreline over Bournemouth after a two-goal second-half cameo from Oumar Niasse.
In the evening fixture, Liverpool's defence was imperfect once again but goals from Mohamed Salah, Philippe Coutinho and Jordan Henderson earned the Reds a 3-2 win over Leicester City.
The busy Saturday schedule is a consequence of five clubs playing Champions League matches on Tuesday and Wednesday the following week.
The sole Sunday fixture was between newly promoted Brighton and Newcastle United, with Chris Hughton's Seagulls triumphing 1-0 thanks to a Tomer Hemed strike. That result sees them move ahead of Everton into 13th.
On Monday night, Arsenal moved themselves into the top half of the table with a 2-0 win over West Brom courtesy of a pair of Alexandre Lacazette goals.