The Gunners have won 18, drawn 21 and lost just 10 of the 49 games these two teams have played in the modern English top flight, with their 50th meeting coming Sunday at White Hart Lane.
As the page turns to the second half of the first century of matches, however, it is Spurs who look to be in the ascendancy and poised to improve their existing record.
THE POCHETTINO EFFECT
This is Mauricio Pochettino's sixth north London derby in the Premier League and he remains unbeaten through his first five. He is the first Spurs manager to achieve such a feat.
The Argentine has won one and drawn one at home and drawn all three of the games played at the Emirates Stadium, and given Arsenal have scored equalisers in the 74th minute or later on three occasions he might consider himself unfortunate not to boast an even better record.
The most recent derby ended in a 1-1 draw despite the fact Spurs were without Dele Alli and Toby Alderweireld and had Harry Kane, who scored their only goal, playing his first game after an injury.
Head-to-head under Pochettino
|Arsenal||1-1||Tottenham||Nov. 6, 2016|
|Tottenham||2-2||Arsenal||Mar. 5, 2016|
|Arsenal||1-1||Tottenham||Nov. 8, 2015|
|Tottenham||2-1||Arsenal||Feb. 7, 2015|
|Arsenal||1-1||Tottenham||Sep. 27, 2014|
For Arsene Wenger, meanwhile, this is the first time during his reign in charge of Arsenal that he has gone five league games against Spurs without a victory. The Gunners had won four of the previous five - including a pair of 5-2 victories - before Pochettino arrived in the capital.
One thing even Pochettino has been unable to do thus far is watch his side keep a clean sheet against Arsenal. Wenger's team has scored in 22 of their past 23 visits to White Hart Lane in all competitions, and only Liverpool vs Spurs has generated more Premier League goals (140) than this fixture (139).
KANE DOES THE DAMAGE
Pochettino's top weapon in these games, unsurprisingly, has been Harry Kane.
Like his manager, Kane is leading Spurs into a brighter era against Arsenal. The striker has netted five Premier League goals against the Gunners, tying Gareth Bale for the all-time best in a Tottenham shirt.
Kane has netted that total in his past four meetings with Arsenal alone, scoring both goals - including an 86th-minute winner - to cancel out Mesut Ozil's opener in Spurs' only win under Pochettino in February 2015.
The 23-year-old will be looking to break Bale's record on Sunday and enters the match in good form, having netted 10 goals in his past nine games in all competitions.
TOTTENHAM'S NEXT STEP
Spurs have made plenty of progress already against Arsenal, then, but could take a few more significant strides this season.
In addition to Kane having the chance to become their all-time top scorer in the Premier League against their arch-rivals, Tottenham are looking to finish above Arsenal for the first time under Pochettino.
They have had an opportunity to do that in each of his two full seasons in charge, leading the Gunners in the table in both campaigns after the second north London derby was played.
LAST SIX GAMES
Arsenal eventually finished 11 points ahead of Spurs in 2014-15, however, before Pochettino's side collapsed towards the end of 2015-16, allowing Wenger's men to sneak up and beat them to second place by a single point.
This season they have already all but ensured 'St Totteringham's Day' - the name given by Arsenal fans to the day it is mathematically confirmed that they will finish above Tottenham - will not be celebrated, and they can guarantee it with a win at White Hart Lane.
If they do so they will have avoided defeat against Arsenal for a sixth consecutive game, which they have never done before in the Premier League era.