The Partenopei went down 2-0 in last week’s first leg in London, but will remain optimistic of progression considering they have lost just once in 16 home matches in this competition.
Having run out 2-0 winners in their previous home game against this opposition in 2013, they are 7/10 (1.70) favourites with bet365 to at least restore some pride with a victory.
Unai Emery’s men have lost both of their knockout stage matches on the road this season, and are 15/4 (4.75) outsiders to book their place in the semi-finals with an impressive win, or 29/10 (3.90) to do so with a draw.
Raul Albiol is unlikely to feature despite returning to training this week, while Amadou Diawara is also doubtful.
Lucas Torreira is a doubt after coming off with a groin injury against Watford on Monday, with Rob Holding, Hector Bellerin and Danny Welbeck all long-term absentees.
Fortress San Paolo
The Gunners will be extremely relieved to be visiting a notoriously difficult away ground with the luxury of a two-goal cushion given their poor record on the road.
Arsenal have lost seven of their last 12 fixtures away from home, with their only victories in that period coming at Blackpool, Huddersfield and a Watford side that played the majority of the match with 10 men.
This hardly inspires confidence for a trip to a stadium where Carlo Ancelotti’s team has won 16 out of 22 matches this season, with Juventus the only away team to leave with three points.
All in all, those 7/10 (1.70) odds seem like solid value on Napoli ensuring the tie is strongly contested by coming out on top in their fortress of a home stadium.
All odds correct at time of publish. Please gamble responsibly.