Whereas the Porcupines bounced back from defeat with a valuable away victory over Eleven Wonders, the Phobians suffered their second successive lose with a defeat to Elmina Sharks on the road.
In Techiman, Abdul Fatawu Safiu's double and Evans Owusu's strike handed Kotoko a 3-0 win, taking them top of the standings in Zone A
A 75th-minute Kofi Agbesima penalty handed Bechem United a 1-0 home win over Berekum Chelsea. The Hunters sit third on the table while the Blues are second from bottom.
The game between Medeama and Stallions FC (formerly Wa All Stars), meanwhile, has been rescheduled.
In Zone B, Hearts suffered another disappointment, following the midweek loss to Elmina Sharks, as they fell to another 1-0 reversal - this time to Karela United. Solomon Sarfo Taylor's strike was the deciding factor. Karela top Zone B while the Phobians are third from bottom.
In Dawu, Dreams FC finally registered their first win of the season courtesy of a 1-0 triumph over bottom-placed Ebusua Dwarfs, who have lost all three games played thus far. Razak Cromwell's goal has sent Still Believe to fifth on the table.
While Elmina Sharks and Wafa settled for a goalless draw at the Nduom Sports Stadium, Simon Zibo scored in the 70th minute to steer Liberty Professionals to a 2-1 home victory over Inter Allies.
Elvis Kyei Baffour opened the scoring for the Scientific Soccer Lads in the 12th minute before Effiong Nsungusi Junior drew parity for the Eleven-Is-To-One in the 67th minute.