The 27-year-old had just a 16-day summer break owing to his commitment with his national team at the Africa Cup of Nations – where the Teranga Lions lost 1-0 to Riyad Mahrez’s Algeria in the final.
However, the former Southampton forward has dismissed any question about his readiness to start for Jurgen Klopp’s side on Wednesday.
“Yes, I think I'm ready [to start]," Mane is quoted as saying on Liverpool’s official website.
"Tiredness, I think, is here [pointing to his head] – for sure.
“I've been playing professional football a long time [and] I think I never even had holidays for more than 20 days [for the last] seven years now.
"I'm used to it and, for sure, I'm ready. I'm here, so let's do it."
The Senegal international made a cameo appearance in Liverpool’s 4-1 thumping of Norwich in the Premier League opener on Friday - coming on for Divock Origi in the 74th minute.
He will hope to carry on his superb form on the continent for the Reds after notching four goals in the run-up to the Champions League title last season, including a brace against Bayern Munich the Round of 16.