The Frenchman has sat out the last three league fixtures as a result of his suspension, but did feature in Wednesday's shock 2-1 Carabao Cup quarter-final defeat to Bristol City as well as a Champions League tie.
United are missing Antonio Valencia for the match at the King Power Stadium - the last in the English top flight before Christmas - so Victor Lindelof appears set to start at right-back in his absence.
Marouane Fellaini, Eric Bailly, Matteo Darmian and Michael Carrick are also out, but Juan Mata is among those returning to the XI as Jose Mourinho reverts to a more conventional look having made 10 changes in midweek.
Zlatan Ibrahimovic is on the bench having scored in his 68-minute run-out against Bristol City, his first start in eight months following knee surgery.
Leicester City have a more familiar look to their line-up than they did in their penalty loss in the cup to Manchester City on Tuesday, with Jamie Vardy and Riyad Mahrez among those returning.
Wilfred Ndidi missed that clash due to suspension but is immediately reinserted into Claude Puel's midfield having served his one-match ban.
Leicester City: Schmeichel; Simpson, Morgan, Maguire, Fuchs; Mahrez, Ndidi, Iborra, Albrighton; Gray; Vardy.
Subs: Hamer, King, Slimani, Dragovic, Okazaki, Chilwell, Amartey.
Manchester United: De Gea; Lindelof, Smalling, Jones, Young; Pogba, Matic; Mata, Lingard, Martial; Lukaku.
Subs: Romero, Ibrahimovic, Rashford, Shaw, Mkhitaryan, Herrera, Rojo.