Neither Pep Guardiola nor Jose Mourinho have enjoyed the kind of instant success they might have hoped upon taking charge at their respective clubs, though City, at least, look set to book their spot in next season's Champions League.
United, on the other hand, look to have more chance of doing that through the Europa League than the Premier League and will take a squad stretched by injuries across the city to face their rivals.
|Game||Manchester City vs Manchester United|
|Date||Thursday, April 27, 2017|
|Time||20:00 GMT, 15:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on Sky Sports 1 and by stream via Sky Go.
|UK TV channel||Online stream|
|Sky Sports 1||Sky Go|
In the US, the match will be available to watch live on television on NBCSN and by stream via NBC Sports Live.
|US TV channel||Online stream|
|NBCSN||NBC Sports Live|
SQUADS & TEAM NEWS
|Position||Man City players|
|Defenders||Kompany, Zabaleta, Kolarov, Clichy, Otamendi, Adarabioyo|
|Midfielders||Fernando, Navas, De Bruyne, Delph, Silva, Fernandinho, Toure, Sane, Garcia, Diaz|
|Forwards||Sterling, Aguero, Iheanacho, Nolito, Jesus|
Sergio Aguero is expected to be fit despite suffering an injury against Arsenal and Fernandinho is definitely available. Guardiola is more concerned, however, about David Silva, who was also forced off against the Gunners.
Gabriel Jesus is also back in training and could feature but Bacary Sagna and John Stones are unlikely to be ready and Ilkay Gundogan remains out.
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero|
|Defenders||Blind, Shaw, Valencia, Darmian, Fosu-Mensah, Bailly, Tuanzebe|
|Midfielders||Carrick, Young, Herrera, Fellaini, Lingard, Mkhitaryan|
|Forwards||Martial, Rooney, Rashford|
Paul Pogba, Marcos Rojo, Zlatan Ibrahimovic and Juan Mata are definitely out for United and though Mourinho has urged them to speed up their recoveries, it would be a surprise to see Chris Smalling or Phil Jones feature.
The good news for Mourinho is that Ander Herrera is available despite suffering an ankle knock in the win at Burnley at the weekend.
BETTING & GAME ODDS
Man City are 10/11 favourites to win at home, according to Oddschecker, with United priced at 7/2 and the draw available at 14/5.
Sergio Aguero is the 7/2 favourite to score first, with Gabriel Jesus next at 5/1. Marcus Rashford is the top choice for the Red Devils at 15/2.
The Manchester derby is yet to become the kind of global, Clasico-comparable event it was expected to morph into when Sheikh Mansour completed his takeover of Manchester City in 2008.
There was that 2011-12 season, when Manchester United thought they had won the title until Sergio Aguero took it off of them with the last kick of the last game of the season, but after reclaiming the championship Sir Alex Ferguson retired and United have not been in contention since.
After a medicore first season at the helm, Jose Mourinho will hope to change that by splashing more money on players of Paul Pogba's ilk this summer, with Antoine Griezmann regularly named as the Red Devils' top target.
There will be major spending at City, too, who do not have any young, core pieces in defence at all beyond last year's £47.5 million addition John Stones.
As far as the two Manchester clubs' attempts to compete with the very best in world football go, however, both Mourinho and Pep Guardiola still have plenty of work to do.