The Reds' rivals in the race for a top four finish - Manchester City, Manchester United and Arsenal - all dropped points at the weekend and Jurgen Klopp's charges took full advantage with a vital victory at Vicarage Road.
Emre Can scored the only goal of the game against the Hornets in spectacular style and Liverpool know that a place in next season's Champions League will be within their grasp should they take all three points against the Saints; the men from Merseyside can be backed at 6/10 (1.60) with dabblebet to win this weekend.
Southampton, though, will provide stiff opposition, for Claude Puel's team have avoided defeat in three previous meetings with the Reds this season; indeed, the team from Hampshire were 1-0 winners on their last visit to Anfield - the second leg of the EFL Cup semi-finals back in January.
Puel's men can be backed at 9/2 (5.50) to repeat the feat, while the same firm go 3/1 (4.0) that Saints secure a share of the spoils on Sunday - a selection that would have seen punters profit from the Premier League meeting between the sides at St Mary's earlier in the campaign.
Only Chelsea have found the net more regularly than the Reds in the top-flight this term, but Klopp's men have yet to score against Southampton this season and there is 11/2 (6.50) that the men from Merseyside again draw a blank against Puel's outfit, with 9/1 (10.0) that the Saints win to nil - a selection that would have landed in both of the previous two ties between the teams.
Southampton missed a last-gasp penalty as they were held to a 0-0 draw against Hull City on home soil last week, but Puel's team have been more clinical on their travels, scoring in each of their last eight matches away from St Mary's - including two in an agonising 3-2 defeat in the League Cup final against Manchester United at Wembley.
Furthermore, the Saints have scored 12 goals in their last five league games on the road.
Goals have proven hard to come by in matches between these teams so far this season, but backing the generous 6/4 (2.50) for more than three goals to be scored when this rivalry is renewed could provide punters with a path to profit ahead of Sunday's clash.
The selection would have landed in three of Liverpool’s last five league matches at Anfield, as well as in four of the Saints’ last six games away from St Mary’s in all competitions.