A single goal from Mario Mandzukic was enough to see Juve past Roma in a 1-0 win in Turin on Saturday.
The Giallorossi's woes are in stark contrast to the form enjoyed by Massimiliano Allegri's charges, who have gone from strength to strength since the summer arrival of Cristiano Ronaldo.
Indeed, this latest win sees the team enter uncharted territory for an Italian club at the start of a Serie A season.
With 16 wins out of 17 so far Juventus have set a new record in the top flight, with no other Italian club in history managing just a strong opening.
16 - Juventus have won 16 of the first 17 games: record in a single Serie A season. Invincible. #JuveRoma— OptaPaolo (@OptaPaolo) 22 de diciembre de 2018
Ronaldo drew a rare blank on Saturday, having netted 11 times so far in his maiden Serie A season.
Instead, it fell on Mandzukic to deliver at home, a role to which he is becoming accustomed.
The Croatian has now scored in his last three home games for Juve, and in total has netted six goals in front of the Bianconeri faithful in 2018-19 - both personal season bests.
He also broke his duck against Roma, against whom he had never previously scored in the teams' Serie A bouts.
And while Juve’s attack has been strong, the club have been hard to break down as well.
The Italian champions have now kept 22 clean sheets on the year, more than any other team in Europe’s top five leagues.