Defeat against the Three Lions would leave the Scots with a paltry return of just seven points from their opening six qualification matches - and their hopes of reaching Russia hanging by a thread.
Another painful defeat against the Auld Enemy would place Strachan's position as manager in serious doubt as the Scots, who last reached a tournament back in 1998, reflect on yet another failed qualification campaign.
The former Celtic and Middlesbrough manager, who scored for Scotland at the 1986 World Cup, initially brought some stability back to the side following his appointment in 2013, but failure to secure, at least, a play-off place in Euro 2016 qualification saw some sections of the Tartan Army grow increasingly impatient with Strachan.
As such, the 60-year-old's position is certain to come under intense scrutiny should Strachan's men fail to see off Gareth Southgate's side at Hampden Park on Saturday evening - and Paddy Power offer an intriguing market on who the Scottish Football Association may turn to in an attempt to revive the national side's flagging fortunes.
David Moyes, who resigned from his role as Sunderland boss following the Black Cats' relegation from the Premier League last season, heads up the market with 5/4 (2.25) that the former Manchester United and Real Sociedad boss takes up the reins.
Alex McLeish, who previously held the post before leaving to take charge of Birmingham City, is the next in line at 21/10 (3.10) to return to the role in the event of Strachan's departure and the former Rangers boss may well prove to be a popular choice with supporters.
Paul Lambert, who has recently left Wolverhampton Wanderers, is an interesting contender at 13/2 (7.50). The former Norwich City, Aston Villa and Blackburn Rovers manager was considered in many quarters to have performed solidly during a seven-month stint at Molineux and, should the 47-year-old fancy a break from club management, the lure of leading his country could tempt Lambert back north of the border.
Steve Clarke is considered as a 17/2 (9.50) chance to take up the post, although the 53-year-old Scot has been out of work since leaving Aston Villa in October, while Clarke has not managed a team in his own right since being sacked by Reading in December 2015.
Northern Ireland manager Michael O'Neill is a 10/1 (11.0) chance, but it would be a major surprise should the SFA persuade the Northern Ireland boss to swap his current position for a similar role within the Scottish setup, while the 12/1 (13.0) quote on offer for Sir Alex Ferguson to come out of retirement to take charge the national team seems incredibly short.
One intriguing contender at longer odds is Alex Neil. He is well regarded despite his departure from Carrow Road back in March and the former Norwich City boss may well fit the profile that the SFA has in mind for Strachan's successor.
Paddy Power go 20/1 (21.0) that Neil replaces Strachan and that price could well represent decent value for punters in a crowded market.
|Alex Neil to be next permanent Scotland manager at 20/1 (21.0) for a 1pt stake with Paddy Power|