The Turk Telekom Arena outfit have a poor record in recent Istanbul derbies, having picked up just a solitary win in their last 15 attempts.
Furthermore, the result of Sunday's game would be decisive in their charge for the Turkish Super Lig title.
“With the support of our fans, we want to give 100 percent and win the game,” Onyekuru told Turkish outlet Hurriyet Daily News.
Fatih Terim’s side are placed second in the log with 60 points, two adrift of leaders Istanbul Basaksehir, after 30 games.
With four matchdays to the end of the campaign, they must win all their games, including a potential top-of-the-table clash with Basaksehir, which is the penultimate 2018-19 tie.
“We have four games ahead that we should win," Onyekuru added.
“My biggest aim is to win the title. We will all see what is next after that.”
This season, Onyekuru has scored 12 goals in 27 Turkish top-flight games.
The Super Eagles are drawn in Group B alongside Burundi, Guinea and Madagascar.