Nevertheless, having run out 2-0 winners against this opposition at this summer’s World Cup, they are priced at 1/2 (1.50) with William Hill to secure a morale-boosting victory at the Stade de France.
Oscar Tabarez’s team have lost each of their last three matches, but are available at 11/2 (6.50) to pull off a shock victory over the world champions.
Four of the last six encounters between this pair have resulted in draws, and you can get odds of 16/5 (4.20) on them cancelling each other out once again.
Dider Deschamps is set to shuffle his pack following the Netherlands defeat, meaning Alassane Plea and Ferland Mendy could be in line for their senior international debuts.
Fernando Muslera, Diego Godin, Jose Gimenez, Sebastian Coates, Gaston Silva, Marcelo Saracchi, and Cristhian Stuani are the headline absentees from a severely depleted travelling squad.
Although missing the spine of their famous backline, La Celeste can at least still call upon star strikers Luis Suarez and Edinson Cavani in Paris.
Cavani will be particularly keen to shine in the city where he plays his club football for PSG, and should stand a strong chance of getting on the scoresheet against a team that has rarely looked solid in exhibition matches.
In fact, the hosts have just one clean sheet to their name in the last seven friendlies, conceding to both USA and Iceland in the most recent two.
While Uruguay’s attacking talent should ensure they join that pair in firing past France, their own defensive absentees make odds of 6/5 (2.20) look very appealing on goal being scored at both ends.