After facing the world champions at Wembley, the Three Lions will play Brazil in London four days later.
Gareth Southgate will hope to test his side against top-class opposition ahead of next summer's World Cup but is without a number of key players.
|Game||England vs Germany|
|Date||Friday, November 10|
|Time||20:00 GMT / 15:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live and for free on television on ITV and by stream via ITV Player.
|UK TV channel||Online stream|
In the US, the match will be available to watch live on television on FS2 and by stream via Fox Sports Go.
|US TV channel||Online stream|
|FS2||Fox Sports Go|
SQUADS & TEAM NEWS
|Goalkeepers||Hart, Butland, Pickford|
|Defenders||Cahill, Walker, Jones, Stones, Bertrand, Rose, Keane, Trippier, Maguire, Gomez|
|Midfielders||Young, Dier, Lingard, Livermore, Loftus-Cheek, Cork|
|Forwards||Vardy, Rashford, Abraham|
England's midfield and attack has been hit hard by injury absences, with Harry Kane, Dele Alli, Jordan Henderson, Raheem Sterling, Fabian Delph, Harry Winks and Adam Lallana all unavailable.
Southgate has hinted that he will continue to experiment with a three-man defence against Germany.
Potential starting XI: Butland; Jones, Stones, Cahill; Walker, Dier, Livermore, Young; Lingard, Vardy, Rashford.
|Goalkeepers||Trapp, Leno, Ter Stegen|
|Defenders||Sule, Plattenhardt, Ginter, Hummels, Rudiger, Boateng, Kimmich, Halstenberg|
|Midfielders||Khedira, Draxler, Kroos, Ozil, Can, Younes, Gotze, Brandt, Gundogan, Rudy, Sane|
|Forwards||Wagner, Werner, Stindl|
Germany will be without a pair of veterans in Manuel Neuer and Thomas Muller, while Leon Goretzka and Shkodran Mustafi are also out.
Joachim Low utilised a 3-1-5-1 formation against Azerbaijan to give his team plenty of firepower but may revert to a more orthodox 4-2-3-1 system here.
Potential starting XI: Ter Stegen; Kimmich, Boateng, Hummels, Plattenhardt; Khedira, Kroos; Sane, Ozil, Draxler; Wagner.
BETTING & MATCH ODDS
Germany are 11/10 favourites to win, according to dabblebet, with England priced at 12/5 and the draw available at 9/4.
It is hard to think of a time in recent history when there has been a greater gap between Germany and England.
The world champions, under the guidance of 11-year coach Joachim Low, are a well-oiled machine. Low is spoilt for choice when it comes to talent but whoever he does pick fits in to a well-established framework.
Germany have a basic identity, usually lining up in a 4-2-3-1 formation, but the versatility of players like Joshua Kimmich enables them to make adjust their shape as needed.
England, on the other hand, have felt fairly close to square one since Sam Allardyce was dismissed before he could even really get started.
There is quality at Southgate's disposal - though much of it will miss this match due to injury - but no clearly defined plan A that England can build from.
They go into this pair of international friendlies likely to continue their experiment with a three-man defence in a bid to establish some semblance of consistency ahead of next summer's World Cup.