However, the France star is among the substitutes in what is a welcome boost to head coach Ernesto Valverde's attacking ranks.
Lionel Messi and Luis Suarez have both been rested, with captain Andres Iniesta among the other players who did not travel, while Paco Alcacer and Samuel Umtiti are injured.
Jose Arnaiz is given a chance to impress in an attacking role in the absence of Messi, Suarez and Alcacer.
Goalkeeper Marc-Andre ter Stegen is rested with Jasper Cillessen handed a start between the posts, while fringe players Denis Suarez, Lucas Digne, Aleix Vidal and Andre Gomes all start.
Ter Stegen joins Dembele on the bench, as do Javier Mascherano, Ivan Rakitic and Jordi Alba.