As if a 3-0 deficit against Barcelona wasn't hard enough, Liverpool will play the second leg of their Champions League semi-final without two key players.
Mohammed Salah hasn't recovered from the head injury that he sustained against Newcastle on Saturday, meaning the Premier League's leading scorer joins Roberto Firmino on the sidelines for the visit of the Catalan giants.
Liverpool are available at an industry best 18/1 (19.0) with bet365 to pull off a remarkable turnaround at Anfield. That price has moved significantly from the initial 10/1 (11.0) quote immediately following the first meeting, largely due to the absences for the hosts.
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Goals from former Liverpool striker Luis Suarez and a Lionel Messi double at the Camp Nou see Barca at just 1/50 (1.02) to progress from the tie.
Indeed, Jurgen Klopp's side are only marginal favourites to win the second leg with bet365 going 6/4 (2.50) about the Reds coming out on top. When the market was originally formed, that price was around Even money (2.0) but there has been plenty of support for the visitors to compile Liverpool's misery.
A Barcelona win at Anfield is now just 17/10 (2.70) from 5/2 (3.50) after Ernesto Valverde rested most of his first-choice line-up for the weekend clash with Celta Vigo. A draw is available at a best price of 29/10 (3.90) with the online firm.
Despite drawing a blank at the Camp Nou, the bookmakers expect an open second leg with both teams to score an 8/15 (1.53) chance with bet365.
Without Salah and Firmino, even more of the goalscoring expectation will fall on Sadio Mane. The Senegal international failed to convert in the first leg but bet365 offer 13/8 (2.63) that he finds the net on home soil.
Messi is a 5/6 (1.83) chance to add to his Champions League tally for the campaign. Suarez can be backed at 11/8 (2.38) to find the net for the second consecutive match in this competition having failed to register a goal in over a year before breaking the deadlock when the teams met for the first time.
bet365's latest Champions League betting sees Barcelona as 4/9 (1.44) outright favourites while Liverpool are 18/1 (19.0) outsiders of the four remaining runners. Anyone looking to back Klopp's side is advised to simply take the 18/1 (19.0) about the Reds to qualify given the two outcomes are trading at the same price.
Odds correct at the time of publish. Please gamble responsibly.