The home side can close the gap on the European places to just a single point if they win at the Stadio Olimpico and 888Sport go 1/3 (1.33) that Simone Inzaghi's men come out on top.
The visitors are only three points clear of the relegation zone and are far from assured of their place in the top-flight next season.
It's tough to trust Lazio based on their recent displays though, with two defeats in their last three outings. A return to home soil after losing to Milan last time out should help, but there's little to like at the current prices in terms of the match odds.
Both teams to score is an industry-best quote of 21/20 (2.05) at 888Sport and has landed in 10 of Lazio’s league games in front of their own fans this season. That said, the visitors have only netted 30 times this campaign, the third-worst tally in the Italian top-flight.
The best approach for punters looks to be opposing a big home win. Udinese may only have won once on the road in Serie A this season but they're rarely on the wrong end of a heavy defeat.
888Sport offer 7/10 (1.70) on the visitors with a +2 European handicap, which would pay out if Igor Tudor's men don't lose by two or more goals.
With the home side hitting a rough patch of form, they seem unlikely to blow away a team that still have plenty to play for. Lazio won the reverse fixture 2-1 and a similar result here would be enough to land this selection on Wednesday evening.