The Red Devils suffered a disappointing 3-1 loss to fierce city rivals Manchester City for their fourth loss of the season just before the international break.
For the Eagles, a 1-0 home loss to fellow London side Tottenham Hotspur a fortnight ago was their eighth defeat of the campaign which has left them just one point from the drop zone.
They’ll need all they can get to a win here as they are quoted at a huge (7.50) as underdogs.
A draw is offered at the price of (5.00) with the same firm.
United are unbeaten in their last 20 league games against Palace, winning the last 11 on home soil without conceding.
Even though Jose Mourinho’s men have failed to keep clean sheets consistently this season, the struggles of Roy Hodgson’s men upfront could play into their hands and are hence (2.20) to win to nil with Bet365.
Odds correct at the time of writing. Please gamble responsibly.