Following a slow start to Group B, Spurs have rallied and a 1-0 victory over Inter a fortnight ago means that their destiny is in their own hands.
Barca have already sealed both qualification and top spot, and with a dogfight on their hands for the Primera Division title, it may be that their focus lies elsewhere for the clash.
Mauricio Pochettino will aim for his side to take advantage and seal the win that would secure progress.
|Game||Barcelona vs Tottenham|
|Date||Tuesday, December 11|
|Time||8pm BST / 3pm ET|
|Stream (US)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How To Watch
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|US TV channel||Online stream|
|TNT USA, Univison Deportes En Vivo||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on BT Sport 3 and streamed via the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 3||BT Sport App|
Squads & Team News
|Goalkeepers||Ter Stegen, Cillessen|
|Defenders||Semedo, Pique, Lenglet, Alba, Vermaelen, Miranda|
|Midfielders||Rakitic, Busquets, D. Suarez, Arthur, Vidal, Alena|
|Forwards||Coutinho, L. Suarez, Messi, Dembele, Munir|
Barcelona are without starting defenders Samuel Umtiti and Sergi Roberto due to injury, while Rafinha and Malcom are also sidelined.
Lionel Messi, Gerard Pique, Jordi Alba and Luis Suarez are among those to be rested.
Ousmane Dembele starts despite his off-the-field indiscretions, while there is also a place for Munir El Haddadi.
Confirmed Barcelona starting XI: Cillessen; Semedo, Lenglet, Vermaelen, Miranda; Rakitic, Alena, Arthur; Dembele, Munir, Coutinho.
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Walker-Peters, Alderweireld, Vertonghen, Rose, Davies|
|Midfielders||Dier, Sissoko, Eriksen, Alli, Lamela, Skipp, Winks|
|Forwards||Kane, Lucas, Llorente, Son|
Injury problems continue to count against Mauricio Pochettino, who is without Davinson Sanchez, Kieran Trippier and Mousa Dembele.
On top of those issues, they are also without Serge Aurier, Juan Foyth and Victor Wanyama.
Kyle Walker-Peters is handed a big responsibility at right-back, but the manager has said he “trusts” the youngster, who recently signed a new deal.
Confirmed Tottenham starting XI: Lloris; Walker-Peters, Alderweireld, Vertonghen, Rose; Sissoko, Winks, Eriksen; Son, Kane, Alli
Betting & Match Odds
Tottenham are 5/2 outsiders, according to bet365, who have Barcelona priced at 19/20 to win the game. The draw is a 10/3 shot.
Having collected just one point from their opening three Champions League matches, Tottenham have done remarkably well to pull the situation round into a favourable one.
So long as Spurs match or better Inter’s result against PSV, they will be through, and manager Mauricio Pochettino has admitted that he will be closely following the fortunes of the Italian club.
“Of course, I'm not going to lie, we'll know what's going on there,” Pochettino told reporters.
“We will be attentive, but we will focus on our match. It is important to know, but also to be concentrated in Camp Nou.
“We are going to be ready to compete in our best condition. It is such an important game and you need to give your best, preparing not only physically but mentally, thinking what you're going to do, not what Barcelona are going to do.”
Certainly, there is little incentive beyond pride for the Catalans to go at this game at full throttle. With 13 points, first place is safely secured, although head coach Ernesto Valverde has pledged that he will ask the team he deploys to go after the win with everything they can.
“We will go out to win but we respect the competition and we want to win,” he said, though ominously added, “we have to look after ourselves.”
Regardless of Barca’s motivation levels, they have a formidable home record against English opposition, having lost just one of 30 European fixtures at Camp Nou versus clubs from the country.