Real Madrid make the trip to the south of the Spanish capital to play their final ever game at the Estadio Vicente Calderon. Atletico will move to a new ground next season, and Los Blancos
will be hoping to ensure that their neighbours avoid a memorable and historic comeback in the second-leg of the Champions League semi-final.
Leading 3-0 from the first-leg, Madrid will head to the Calderon aiming to score, knowing that an away goal in the final Madrid derby at one of their favourite stomping grounds until only recently would leave Atleti needing to score five times.
Last week, it was Cristiano Ronaldo who stole the headlines as his 42nd Real Madrid hat-trick, and second against Atletico this season, gave Los Blancos a commanding lead. Ronaldo has scored 21 times in Madrid derbies and can be backed at 9/10 (1.90) to score at anytime with bet365 while he is offered at 10/3 (4.33) to open the scoring.
The current Balon d'Or holder can also be backed at 4/1 (5.00) to score two or more, and at 16/1 (17.00) to score another hat-trick and given his current scoring form in Europe, there could be some value in backing him to get among the goals once more.
Atletico's hopes will be placed primarily on the shoulders of Antoine Griezmann who had a quiet game in the first-leg, with the Frenchman knowing he will have to be at his best if he is to inspire an improbable comeback.
His compatriot Kevin Gameiro should have found his name on the scoresheet too, spurning Los Rojiblancos's best chance in the first half of last week's match, and the former Sevilla forward is offered at 6/4 (2.50) to score at anytime.
Elsewhere in the betting, Alvaro Morata and James Rodriguez both scored a brace in Real Madrid's 4-0 league win at Granada at Saturday, although their chances of making the starting XI on Wednesday night are slim.
More guaranteed of a starting berth is Saul Niguez for Atletico and the Spain international has been in decent scoring form of late, netting three times in his last six matches. The 22-year-old has a penchant of finding the back of the net in big games and will be eager to leave his mark at what will be the final Madrid derby at the Vicente Calderon.
He scored the winner for Atleti on Saturday against Eibar and there could be some interest in backing him at 4/1 (5.00) to score at anytime, as he did against Real Madrid at the Calderon in La Liga back in 2015.