Unai Emery's men have won six and lost none of their last eight European fixtures on home turf, but have lost their last two in a row on the road so establishing an early advantage could prove crucial.
Having run out 2-0 winners in their last home game against this opposition in 2013, they are 29/20 (2.45) favourites with bet365 to take control in the tie by coming out on top here.
Seven of the Partenopei's eight defeats this season have come on their travels - including two in their last three away matches - making them 2/1 (3.00) outsiders to put one foot in the semi-final with a victory in London.
Just one of this pair's combined 14 matches in this season's competition has resulted in a draw, but you can get odds of 5/2 (3.50) on this one finishing up all square.
Granit Xhaka and Laurent Koscielny are doubts after missing Sunday's 1-0 defeat to Everton, while Rob Holding, Hector Bellerin and Danny Welbeck are long-term absentees.
Amadou Diawara and Raul Albiol are both sidelined for the guests, although Lorenzo Insigne and Simone Verdi should be fit to play after recovering from injury.
With an extremely tricky second leg still to come, the Gunners will be well aware of the need to achieve a positive result in their own back yard.
This certainly looks achievable considering they have lost just twice in their last 25 home games, winning each of the most recent seven in a row.
Tips and Predictions
With Napoli losing five and winning just four of their previous 12 away games, those 29/20 (2.45) odds certainly look appealing on a motivated Arsenal securing a valuable first-leg lead.
Emery's men have struggled on the road themselves this term so backing them to establish an advantage to take to Naples looks worth backing at the current odds.
All odds correct at time of publish. Please gamble responsibly.