Pep Guardiola's men still have their eyes firmly fixed on a historic quadruple, but the Premier League leaders could face a tricky test against the Latics.
Wigan have already beaten AFC Bournemouth and West Ham United at DW Stadium in this competition this term and they can be backed at 14/1 (15.0) with dabblebet to make it a hat-trick of wins against top-tier opposition.
The men from Manchester lost to the Latics in the final of this competition five years ago, but given their domestic dominance so far this season, it is no surprise that they are dabblebet's 1/6 (1.17) favourites here.
The same firm go 13/2 (7.50) that a replay is required to separate the sides.
Gabriel Jesus could make his first appearance of 2018 after returning to training last week.
Wigan captain Sam Morsy misses out through suspension after being booked in the midweek defeat to Blackpool.
Wigan have kept a clean sheet in eight of their last 10 home matches and Cook's charges are available at a chunky 17/2 (9.50) to shut out free-scoring City, who have scored 111 goals in all competitions this season.
Tips and predictions
That being said, City are in fine form and they can claim a comfortable win at DW Stadium against a Latics side that may well find themselves out of their depth against Guardiola's men.
Monday's visitors have scored three or more goals in six of their last eight matches and the 11/10 (2.10) quote from dabblebet for Guardiola's side (-2) to beat the handicap could well prove popular with punters.