West Ham desperately need to get back on track. A 4-0 opening day defeat to Manchester United was compounded by a heartbreaking 3-2 loss to Southampton at St Mary's last weekend, though relief came in the way of a 2-0 Carabao Cup victory over Cheltenham Town in midweek.
And with a game against Newcastle United, themselves in something of a crisis, looming large on the horizon, Slaven Bilic's men have a fine chance to register their first three points of the season.
WEST HAM INJURIES
West Ham are optimistic that both Cheikhou Kouyate and Andy Carroll will be fit to face Newcastle this weekend, while Argentine playmaker Manuel Lanzini has confirmed that he has returned to training ahead of a potential return.
Lanzini, whom the Irons hope will form a prolific link with new striker Javier Hernandez, may not be fit enough to feature from the start, but he could be named on Bilic's bench.
Elsewhere, Winston Reid is injured, after injuring a calf muscle in the warm-up ahead of the club's game against Southampton last weekend.
Robert Snodgrass, meanwhile, is likely to miss out as he continues to be linked with a move away from the club.
WEST HAM SUSPENSIONS
Marko Arnautovic will miss the game after being sent off against Southampton for a vicious elbow on defender Jack Stephens.
Bilic has expressed his displeasure with the £20 million summer signing from Stoke City, and has confirmed that Arnautovic will be fined for his actions.
“You can’t do those kind of things,” Bilic said. “I am fuming, still now – you can feel. I am fuming, but it happened. But no more. Not him, not anybody else. I am confident the message got through.
"The players, they know and they can’t let the team down and also of course him. And whoever does those kind of things will get the fine, of course. He will get fined."
WEST HAM POTENTIAL STARTING LINE-UP
The Hammers fell 2-0 behind against the Saints but launched a stirring comeback, with Hernandez scoring twice to restore parity, even after Arnautovic's sending off.
A last-minute penalty, however, ensured that Southampton took all three points, and Bilic will have to tinker with his line-up this weekend.
With Reid injured, Declan Rice, the 18-year-old, could feature in defence in place of the New Zealand international.
Elsewhere, Arnautovic is likely to be replaced by Diafra Sakho on the left-hand side of an attacking three after the Senegal international scored against Cheltenham in midweek.
NEWCASTLE TEAM NEWS
Newcastle have yet to win a game in all competitions since their promotion to the Premier League.
As tensions between manager Rafael Benitez and owner Mike Ashley continue to bubble, the Magpies sit 17th in the table, and are yet to score a goal in the top-flight.
A 2-0 opening weekend defeat to Tottenham was followed by a disappointing 1-0 loss to fellow promoted outfit Huddersfield Town, while Newcastle were also beaten 3-2 by Nottingham Forest in the Carabao Cup in midweek.
Worse still, Benitez could be without three first-team players against the Hammers.
Dwight Gayle is suffering with illness, while summer signing Florian Lejeune is nursing an ankle problem.
DeAndre Yedlin, meanwhile, is sidelined with a hamstring injury.
BEST OPTA MATCH FACTS
Newcastle United have lost just one of their last 13 Premier League home games against West Ham United (W7 D5 L1).
Newcastle United have lost both of their opening two games to a Premier League season for only the third time. On the other two occasions, they finished the season in the top 11 (3rd in 1993-94 and 11th in 1999-00).
Javier Hernandez has now scored 39 Premier League goals following his brace on MD2 against Southampton; all 39 of these goals have come from inside the box.
This is the fifth time that West Ham United have lost their opening two games to a Premier League season, but they have only been relegated in one of those campaigns (2010-11).
Newcastle United haven’t won a Premier League game in the month of August since 2013; losing five and drawing four of their nine matches in the month since then.
TV COVERAGE & KICK-OFF TIME
The match will kick off at 15:00 BST on Saturday and will not be aired live in the United Kingdom. Highlights will be aired on Match of the Day, which will be shown at 22:25 BST that evening.