After sweeping Lyon aside in emphatic fashion in the Round of 16, Ernesto Valverde's side will be relying on their creativity to carve open United, and they certainly have a number of stars ready to slice through the Red Devils.
In Lionel Messi (67), Ivan Rakitic (61) and Philippe Coutinho (60), Barca have the top three players remaining in the UCL for sequences ending in a shot, while Messi also leads the UCL for sequences ending in a goal (12).
Their creativity extends through to the whole team, too - the Blaugrana have created 46 attacks containing 10 passes or more in this season's UCL; no team has created more.
Watch the video above for the statistics and full breakdown.
Throughout the 2018-19 season, the 'Innovation Champions' series will highlight the Intelligent Movement of Europe's top teams. Follow the series on Facebook at Nissan Football Lab.