Luis Garcia Plaza's side make the short trip south in desperate need of a win, having recorded just one victory in their last 14 matches in the Primera Division.
Valencia, for their part, have only won twice at home in the league all season and will be aiming to improve that record this weekend.
Geoffrey Kondogbia and Goncalo Guedes continue to be absent for Marcelino Garcia's side, although Francis Coquelin should make his return from injury. Centre-back Gabriel Paulista is suspended and will not face his former club.
Villarreal have Bruno Soriano, Manu Morlanes and Dani Raba injured, with Ramiro Funes Mori suspended.
No team in La Liga has played out more draws than Valencia, with their total of 11 stalemates just ahead of Villarreal's nine draws this season.
Between them 20 of these two sides' 40 league matches this term have ended in draws and there must surely be a temptation to back another stalemate.
Seven of Valencia's last ten home La Liga matches have been draws and despite dominating plenty of those games, Los Che have badly lacked a cutting edge in the final third - scoring just 19 goals in 20 matches.
Tips and predictions
The price of 5/2 (3.50) for a draw should be of interest, while for even higher odds invest in a draw with under 2.5 goals at 16/5 (4.20).The latter selection has paid out in all seven of Valencia's home league draws this term.