Juve only won one of their three away games in the group stages last season and 888Sport offer them at 4/5 (1.80) to record a win on Wednesday.
Juventus midfielder Miralem Pjanic picked up an injury on international duty and was an unused substitute at the weekend, so it remains to be seen whether he is fit enough, while veteran defender Andrea Barzagli is set to miss out with a calf problem.
Centre-back Ezequiel Garay has been out for a month with a knee injury and will not play here.
Valencia are still to win a league match this season with three draws and a defeat from their opening four La Liga matches, despite their squad being stronger than last term.
The arrivals of Kevin Gameiro and Michy Batshuayi plus the permanent signing of Goncalo Guedes for a club record fee means Los Che should improve on their total of 65 goals in 38 league games from 2017-18.
In Europe, they will be tested in a difficult group but Juventus have conceded in three of their four Serie A clashes this season, including against Sassuolo, Chievo and Parma, so their trip to Mestalla could yet yield more goals.
Tips and predictions
Both teams to score can be backed at 81/100 (1.81), which looks like an excellent price.
Also worthy of consideration is backing Ronaldo to net at 53/50 (2.06) while Juve are priced at 23/25 (1.92) to score over 1.5 goals which they have done in four of their last five Champions League matches.