Mauricio Pochettino's men started the season with a superb 2-1 win against Newcastle United at St James' Park while the Cottagers saw their return to the top tier soured by a disappointing 2-0 home defeat to Crystal Palace.
Spurs have finished inside the top four in each of the past three seasons and, therefore, it is no surprise to see the hosts as short as 1/4 (1.25) with William Hill to register a win against Slavisa Jokanovic's men.
Fulham are available at a chunky 10/1 (11.0) to stun Spurs by winning at Wembley, while the same firm go 24/5 (5.80) that the Cottagers collect their first Premier League point of the season this weekend.
Harry Kane is still searching for his first Premier League goal during August, an incredible run that now spans 14 matches and 988 minutes.
Son Heung-Min is away on international duty at the Asian Games and, so, will play no part at Wembley.
Denis Odoi is suspended for Fulham, Tim Ream is not expected to be fit to start and Alfie Mawson is out until at least September, but Joe Bryan could play despite limping off against the Eagles last week.
Spurs looked sharp at St James' Park and they will be in the mood to get amongst the goals when they play in front of their home supporters for the first time this term.
As such, William Hill's 10/11 (1.91) quote for Pochettino's side to score in both halves could represent real value for punters ahead of Saturday's match at Wembley.