Nuno Espirito Santo’s have eased past Crusaders and Pyunik to reach this stage, scoring 14 goals and conceding just one.
The Granata have lost just two of their last 22 fixtures in all competitions and are priced at 5/4 (2.25) to take the upper hand in this tie by coming out on top.
Both of the guests’ opening Premier League games have resulted in draws, and you can get odds of 9/4 (3.25) on them settling for another stalemate here.
Iago Falque missed both legs of the last round against Shakhtyor Soligorsk with an ankle injury, and is unlikely to recover in time for this clash.
Matt Doherty will need to be assessed after coming off due to illness at half-time in Monday’s draw with Manchester United.
Although they have scored an average of 3.5 goals per game so far in this competition, it is hard to see Wolves maintaining that prolific streak against a defence that conceded just 37 goals in 38 Serie A games last season – the fifth-best record in the league.
Instead, they are more likely to rely on the resolute backline that has only let in two goals in six matches so far this campaign, in what promises to be a closely-fought encounter.
Indeed, odds of 8/11 (1.73) look well worth backing on no more than two goals being scored in a tight match between two sides that have conceded just three times between them in eight qualifiers so far this summer.
All odds correct at time of publish. Please gamble responsibly.