World Cup favourites USA continue the quest to defend their place at the top of women's international football.
Julie Ertz and Alex Morgan were doubts coming into this game, but coach Jill Ellis has confirmed the pair are available for selection.
Jorge Vilda should have a full squad to pick from for this daunting clash. While some players are walking a suspension tightrope in the last 16, Marta Corredera is the only Spain player to be cautioned in the tournament thus far.
While USA's record-breaking 13-0 win over Thailand on matchday one demonstrated the firepower Ellis can call upon, the tournament favourites have been just as impressive at the back.
This defensive strength goes beyond this competition. The last time USA conceded a goal was in a 5-3 win over Australia in April - eight games ago.
Conversely, Spain have been struggling in the final third. A late rally to beat South Africa in their opening group game was followed by back-to-back goalless performances and that lack of cutting edge could cost them against the best team in the world.
USA to win "to nil" looks the best option for punters.
This selection has landed in seven consecutive games for Ellis' side and at 8/11 (1.73) it is big enough to consider as a single wager. It was a winner in the only other meeting between the pair as USA secured a 1-0 friendly win in January.
A similar scoreline could be on the cards here and those seeking a bigger price should look to a win for the favourites combined with under 2.5 goals which is available at 7/4 (2.75) with bet365.
Odds correct at the time of publish. Please gamble responsibly.