The Blades left it late on their long-awaited top-flight return to salvage a point in their opening game against Bournemouth, but Chris Wilder will hope that the benefit of their first home game will give his side a boost.
Palace too will be looking to pick up their first win of the 2019-20 season too, following a goalless draw on the opening weekend with Everton, but Roy Hodgson will be more than wary of the threat his newly promoted hosts possess.
All eyes will be on the Eagles' selection too, as speculation continues to swirl around the future of Wilfried Zaha, though the forward missed out on a move to a rival English club.
|Game||Sheffield United vs Crystal Palace|
|Date||Sunday, August 18|
|Time||2:00pm BST / 9:00am ET|
|Stream (US)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBCSN||fubo TV (7-day free trial)|
In the UK, the match will be shown on Sky Sports Main Event and Sky Sports Premier League, and available to stream on Sky Go.
|UK TV channel||Online stream|
|Sky Sports Main Event / Sky Sports Premier League||Sky Go|
Squads & Team News
|Position||Sheffield United squad|
|Goalkeepers||Henderson, Moore, Verrips|
|Defenders||Basham, Egan, O'Connell, Jagielka, Stearman, Freeman, Bryan|
|Midfielders||Baldock, Lundstram, Norwood, Fleck, Stevens, Osborn, Besic, Morrison|
|Forwards||McBurnie, Robinson, Sharp, McGoldrick, Mousset|
Sheffield United XI: Henderson; Basham, Egan, O'Connell; Baldock, Lundstram, Norwood, Fleck, Stevens; McGoldrick, Robinson
|Position||Crystal Palace squad|
|Goalkeepers||Guaita, Hennessey, Henderson|
|Defenders||Ward, Kelly, Dann, Van Aanholt, Schlupp, Woods, Cahill|
|Midfielders||Meyer, Milivojevic, McCarthy, Riedewald, Camarasa, Kirby, Kouyate|
|Forwards||Townsend, Benteke, Zaha, Ayew, Wickham|
Crystal Palace XI: Guaita; Ward, Kelly, Dann, Van Aanholt; Townsend, Milivojevic, McArthur, Meyer; Benteke, Zaha
Betting & Match Odds
Sheffield United are the favourites to open their account at home with odds of 31/20 available with bet365. Palace are meanwhile priced at 19/10 while a draw is available at 21/10.
Both Premier League new boys Sheffield United and old hands Crystal Palace will know the importance of picking up their first win of the season when the two meet this weekend in the top flight.
The newly promoted Blades and the oft-inconsistent Eagles are tipped to be among the runners and riders jostling to avoid relegation come the business end of the campaign, with the former widely expected to struggle in their quest to avoid an immediate return to the Championship.
But their manager Chris Wilder has proved himself a capable mind at many levels of the game and, though maligned in some quarters over the years, his opposite number Roy Hodgson is no fool either.
They will each know how vital three points at the expense of the other could prove to be and duly look set to unsheath their biggest weapons in their first meeting since 2011.
United spent big upon their long-awaited return to the high table of English football, with striker Oli McBurnie expected to lead the line following his expensive move from Swansea City.
The forward was named on the bench in last week's 1-1 draw with Bournemouth, as was talismanic attacker Billy Sharp, who eventually proved to be their lifesaver with an 88th-minute goal.
More eyes will arguably drift over to Palace however as they look to continue to fend off interest for their most prized asset, Wilfried Zaha, as speculation continues to rumble on around his future.
But the move never materialised, and nor did a subsequently mooted switch to Everton, with Palace blocking offers that they felt fell short of their hefty valuation of the 26-year-old.
Asked whether the forward could still exit Selhurst Park, Hodgson noted: "You can never rule out the possibility that it might happen because the transfer window in Europe is still open until the end of the month.
"It's not something I'm going to worry about because it's something that I cannot affect. There's not too much point worrying about it, if you ask me would I welcome it, the answer is no.
"I would rather that he gets his head down and commits himself to the season that we've got in front of us and commits himself to helping me, the coaching staff and the players into having another season that we can regard as a good one. That's what I would like."
Zaha was forced to also start from the bench last week, but is likely to feature from the outset at Bramall Lane.