The Egypt international has enjoyed a sensational debut season at Anfield since moving from the Italian capital.
And he came up top again on Tuesday to break the deadlock in the Champions League semi-final first leg.
A delightful curling effort beat Alisson and put Liverpool 1-0 ahead in the first half, and in the process wrote the striker's name into the record books.
And just before half time he was at it again, lofting the ball over the Brazilian goalkeeper for his and the Reds' second.
The 25-year-old would go on to add a pair of assists in the second half, as Liverpool secured a 5-2 victory.
Salah has netted in no less than 32 games this season, the most ever for a Reds player in a single campaign.
Liverpool favourite Ian Rush was the previous record-holder, having scored in 31 different matches back in the 1983-84 season.
Rush still holds the overall mark for goals in a Liverpool season with 47, although with 43 now Salah still has time to overtake the Welsh poacher.
Salah has now scored 10 goals in the Champions League this season, the most by a Liverpool player in a single season in European competition.
Salah wouldn't hold the record alone for long, though, as a second-half double by Roberto Firmino brought him level with his team-mate on 10 goals in Europe this term.
10 - Mohamed Salah has scored 10 goals in the Champions League this season, the most by a Liverpool player in a single season in European competition. King. pic.twitter.com/aJJkiIxis6— OptaJoe (@OptaJoe) April 24, 2018
5 – Mohamed Salah has scored in each of his last five Champions League starts for Liverpool; no player has scored in more successive games for the Reds (also, Steven Gerrard). Magic. pic.twitter.com/4SnEyLhkkE— OptaJoe (@OptaJoe) 24 de abril de 2018
He has also found the net in his last five Champions League starts, a run that only Steven Gerrard has ever previously managed for the Merseysiders.