They will be wary, however, of a Girona side who knocked out Atletico Madrid in the previous round to make the last eight of the competition for the first time in their history.
Real Madrid's last home match against Girona saw them triumph 6-3 in La Liga last March. SportPesa offer the hosts at 5/14 (1.36) while Girona can be backed at 13/2 (7.50). The draw is priced at 15/4 (4.80).
Midfielders Marcos Llorente and Toni Kroos are yet to play a game this year for Real Madrid, but they are both pushing for a return from injury. Marco Asensio and Gareth Bale are likely to remain sidelined for Los Blancos.
Girona had centre-forward Cristhian Stuani suspended for their weekend trip to Real Betis, but the Uruguayan is likely to start on Thursday night having not featured on Sunday.
These two sides have only ever met three times but those games produced 17 goals and no clean sheets, with the most recent clash being a 4-1 Real Madrid win at the Estadio Montilivi in August.
Girona have had few problems scoring away from home this season, netting twice at Camp Nou, three times at the Wanda Metropolitano in the previous round as well as scoring twice at Betis in La Liga at the weekend.
They have scored in all three matches they have contested against Real Madrid and in Stuani they boast the third top scorer in La Liga behind Lionel Messi and Luis Suarez.
Tips and predictions
Both teams to score and over 2.5 goals is offered at 10/11 (1.91) and has paid out in all three previous meetings. Girona have not kept a clean sheet in their last 11 matches but have been scoring regularly, meaning that we should be confident of goals on Thursday.