As a consequence, Rangers have high hopes of reaching the knockout stages and victory at Ibrox on Thursday would represent another significant step towards achieving that objective.
Rangers have been hugely impressive on home soil this season, winning all but one of their 10 competitive matches in Govan, so it is no surprise they are chalked up as 23/20 (2.15) favourites with SportPesa to take all three points from this tie.
Spartak, who are seventh in their domestic league, are a 43/20 (3.15) shot to become the first team to beat the Gers at Ibrox since Gerrard took up the reins, while the same firm go 12/5 (3.40) that the two teams settle for a share of the spoils.
Kyle Lafferty could come back into the starting line-up after being unavailable against Hamilton Academical at the weekend. The Northern Irish striker scored for the Gers against Villarreal in the opening game of the group.
Spartak have sacked Massimo Carrera as manager ahead of Thursday's tussle in Glasgow and fitness coach, Raul Riancho, will be in charge at Ibrox.
Rangers have hit at least three goals in each of their last five fixtures on home soil and SportPesa go 16/5 (4.20) that the Gers grab more than two goals in this game, while the same firm go 5/7 (1.71) that there are goals at both ends.
Indeed, Thursday's hosts have conceded in six of their last seven matches.and may struggle to keep a red-hot Rangers side at bay.
Better value, though, could lie in backing Rangers to claim a vital victory at Ibrox at 23/20 (2.15) with SportPesa.
The selection would have seen punters profit from nine of Rangers' 10 home matches so far this season and could again provide a path to profit on this occasion.