The Nigerian came from the bench to seal his side’s win after Hans Vanaken’s brace had given Philippe Clement’s men a 2-0 half-time lead.
Vanaken gave Club Brugge a third-minute lead from the penalty spot following Brendan Hines-Ike's foul on Eduard Sobol.
The Belgian doubled his lead 18 minutes later after curling in a ball which left goalkeeper Sebastien Bruzzese helpless.
With the hosts comfortably ahead, Okereke replaced Mbaye Diagne in the 62nd minute - and six minutes later, he justified his inclusion with his team's third goal – his seventh of the season.
OKE - REKE! GOAAAAL! 3-0! pic.twitter.com/20CrLVqaDb— Club Brugge KV (@ClubBrugge) November 2, 2019
South Africa international Percy Pau came on as a 65th-minute substitute for Lois Openda but could not add to his two goals scored so far.
For the visitors, Nigeria’s Abdul Jeleel Ajagun and Ezekiel Imoh were thrown into the fray by manager Yves Vanderhaeghe, however, their introduction could not prevent the Guys from losing.
With this result, Club Brugge remain league leaders with 33 points from 13 matches and are six points above closest challengers Standard Liege.
After Wednesday’s clash at Champions League clash at PSG, they travel to Bosuilstadion for a date with Royal Antwerp.