The Juventus forward is yet to take in an appearance for his country since gracing a World Cup stage over the summer.
Ronaldo completed his switch from Real Madrid to Juve shortly after his involvement at another showpiece event came to a close, and he is still adjusting to new surroundings.
With that in mind, the 33-year-old has requested that he be overlooked for international duty.
They are due to face Poland in the UEFA Nations League on October 11, but then taking in a friendly date with Scotland three days later.
Having removed himself from contention for those fixtures, Ronaldo will not be adding to his haul of 154 caps any time soon.
His remarkable international goal haul will also stand at 85 for the foreseeable future, with it yet to be determined whether he be recalled by Portugal during the next round of games in November.
Santos has stated that he expects a five-time Ballon d’Or winner to be back at his disposal at some stage, but no date has been set for his return.
He said: “In the future, nothing prevents Cristiano from giving his contribution to the national team.”