Jose Mourinho and Frank Lampard won this competition together twice while at Chelsea but now the two men meet as managers of opposing sides.
Manchester United have won their last five home competitive encounters with Championship opposition inside 90 minutes and are 1/5 (1.2) to do so again.
Visitors Derby though have made a bright start to their season and are a huge 12/1 (13.0) to cause potentially the biggest upset of the round.
A draw, which would mean a penalty shoot-out, can be found at 11/2 (6.5).
Right-back Diogo Dalot put in an excellent performance against Young Boys in the Champions League and could have a chance to further his claim to start more regularly. Phil Jones, Marcos Rojo and Ander Herrera are all injured.
George Evans and Curtis Davies are unlikely to feature here while Ikechi Anya is a long-term absentee. Although David Nugent normally starts up top for Derby, Lampard might favour the extra pace of Jack Marriott here.
Quiet second half?
Manchester United have only scored three second half goals in their last 11 games in all competitions and Derby have only shipped one in their last nine.
The 12/5 (3.4) on offer for the hosts to fail to score after the interval is therefore tempting as once Mourinho’s side build up a lead of one or two goals, they often hold what they have rather than attack further.
Preview and predictions
Our best bet is the 5/2 (3.5) on offer for Manchester United to win a game involving Under 2.5 goals.
While Derby should give a good account of themselves, we can expect the hosts to do enough work in the first period to progress to the next round.