Cardiff face a ferocious fight for Premier League survival and Neil Warnock's men suffered a sickening setback against Chelsea last time out.
The Bluebirds led until the 84th minute against Chelsea, but conceded two late goals in a 2-1 defeat against Maurizio Sarri's men - the first of which was clearly offside.
Cardiff must pick themselves up from that bitter blow if they are to stand any chance of beating the drop. Wednesday's assignment, however, could barely be more daunting for the relegation-haunted Bluebirds.
Manchester City are red-hot favourites to take all three points from this clash. Indeed, bet365 offer just 1/12 (1.08) that Guardiola's men come out on top.
The enormity of the task facing Cardiff is reflected by bet365's 20/1 (21.0) quote for an away win. The odds compilers offer 10/1 (11.0) that Warnock's charges pick up a precious point from their trip to Manchester.
Sergio Aguero was withdrawn after picking up a knock at the weekend. As such, the Argentine striker may not be risked here. The defending champions have no other injury worries, but Guardiola regularly rotates his talented squad.
Two of Cardiff's key men this season, Callum Paterson and Sol Bamba, will miss the remainder of the campaign. The Bluebirds have no other concerns ahead of the trip to Manchester.
Hosts to cruise
Manchester City were 5-0 winners when they faced Cardiff in this competition earlier in the season and will be hoping for a similarly emphatic victory on this occasion.
The Bluebirds have picked up just eight Premier League points on their travels thus far this term. Warnock's men can be backed at 15/2 (8.50) with bet365 to avoid defeat on this occasion.
The same firm go 20/1 (21.0) that Cardiff keep a clean sheet. Warnock's men have conceded in 11 of their last 13 matches outside of the Welsh capital.
Manchester City look likely to chalk up a comfortable win. As such, bet365's 6/5 (2.20) quote for Guardiola's men (-3) to win by at least four clear goals could represent real value.
This selection has already paid out in six of City's Premier League games this season. Four of those came at the Etihad Stadium and three were against teams currently ranked 16th or below.
With goal difference potentially coming into play in the title race, there is little reason for the holders not to aim for a wide margin victory if they're in the position to run up the score.
Odds correct at time of writing. Please gamble responsibly.