Pep Guardiola's men passed up a golden opportunity to open up a two-point lead at the top of the table when Riyad Mahrez's missed penalty meant that the men from Manchester were forced to settle for a goalless draw at Liverpool before the international break.
Back on home soil, the defending champions will be confident of a return to ways when they take on Sean Dyche's side.
City have lost just one of their last 35 home matches in this competition and have a perfect record on their own patch in the Premier League this term, so it is little surprise that they are chalked up as 1/14 (1.07) favourites with William Hill to win this weekend.
A 2-1 win at Cardiff before the international break ended a nine-match run without an away win in all competitions for the Clarets, but this trip represents a significant step up in class.
Indeed, the enormity of the task facing the visitors is reflected by William Hill's 25/1 (26.0) quote for an away win, while the same firm go 11/1 (12.0) that the Clarets claim a precious point in Manchester.
Sergio Aguero has scored six goals in six games against Burnley in all competitions and should be fit and fresh after being rested by Argentina during the international break. Mercurial midfielder Kevin De Bruyne could make his first start of the season.
Joe Hart will face his former club for the first time after 12 years at City. Stephen Ward faces a spell on the sidelines after undergoing minor knee surgery, whilst James Tarkowski is doubtful and this game is likely to come too quickly for Robbie Brady.
City have scored three or more times in 10 of their last 13 Premier League home wins and with 21 goals so far this season, they are the division's leading scorers. William Hill go just 2/5 (1.40) that Guardiola's side again score more than two goals.
When City are in full flow, they can be hard to contain, while the Clarets appear to lack the solidity that was a hallmark of their success last season for they have managed just one clean sheet in their last 10 outings.
With that in mind, William Hill's 11/10 (2.10) quote for Manchester City to score more than one first half goal could represent real value for punters ahead of this weekend's match.