Hazard returns for the headline encounter while Victor Moses drops to the bench.
Andreas Christensen, a substitute against Atletico, is on from the start against Pep Guardiola's side.
City call upon Gabriel Jesus to start up front in Sergio Aguero's absence after the Argentine damaged a rib in a car accident in Amsterdam during the week.
Fabian Delph keeps his place at left-back following Benjamin Mendy's cruciate ligament tear, while Raheem Sterling is back in the first team after coming off the bench in the win over Shakhtar on Tuesday.
City sit three points ahead of Chelsea ahead of the visit to Stamford Bridge and can go joint-top again with a win, having seen Manchester United move three points clear by beating Crystal Palace earlier in the day.
Chelsea XI: Courtois; Rudiger, Cahill, Christensen, Azpilicueta, Alonso; Bakayoko, Kante, Fabregas; Hazard, Morata,
Man City XI: Ederson; Walker, Stones, Otamendi, Delph; Fernandinho, De Bruyne, Silva (C); Sterling, Jesus, Sane