Quagliarella, whose last Italy cap came in 2010, is included in Roberto Mancini's squad for a Coverciano training camp next week.
The 36-year-old has hit 16 goals in 20 appearances this season to top the Serie A scoring charts ahead of Juventus superstar Cristiano Ronaldo.
Quagliarella has found the net in 11 consecutive appearances in the league, levelling the competition record set by Gabriel Batistuta while playing for Fiorentina in 1994.
Quagliarella's reward for his scoring exploits is a place in Mancini's squad for a camp that will run on February 4 and 5, with the Azzurri preparing for the start of their Euro 2022 qualifying campaign next month.
Scheduling issues mean only Serie A players are in the squad, with Juventus defender Giorgio Chiellini included despite his calf problem. Injured club colleague Leonardo Bonucci, however, is absent.
Italy squad for training camp in full:
Goalkeepers : Gianluigi Donnarumma (Milan), Alex Meret (Napoli), Salvatore Sirigu (Torino)
Defenders : Alessandro Bastoni (Parma), Cristiano Biraghi (Fiorentina), Giorgio Chiellini (Juventus), Andrea Conti (Milan), Domenico Criscito (Genoa), Mattia De Sciglio (Juventus), Alessandro Florenzi (Roma), Armando Izzo (Torino), Manuel Lazzari (SPAL), Alessio Romagnoli (Milan), Leonardo Spinazzola (Juventus)
Midfielders : Nicolo Barella (Cagliari), Marco Benassi (Fiorentina), Bryan Cristante (Roma), Roberto Gagliardini (Inter), Lorenzo Pellegrini (Roma), Stefano Sensi (Sassuolo), Sandro Tonali (Brescia), Nicolo Zaniolo (Roma)
Forwards : Domenico Berardi (Sassuolo), Federico Bernardeschi (Juventus), Federico Chiesa (Fiorentina), Stephan El Shaarawy (Roma), Roberto Inglese (Parma), Lorenzo Insigne (Napoli), Moise Kean (Juventus), Kevin Lasagna (Udinese), Matteo Politano (Inter), Fabio Quagliarella (Sampdoria)