Isco admitted Real Madrid team-mate Gareth Bale is having a hard time after the injury-ravaged Welsh star suffered a groin strain.
Bale's injury woes worsened on Friday following news that he is facing up to a month on the sidelines after another setback.
The 28-year-old, who has been restricted to just nine appearances in all competitions this season, was in line to return ahead of next week's La Liga derby against Atletico Madrid until confirmation of a strained adductor muscle in his left leg.
"He's having a hard time."
The Wales international started that match but limped off during the closing stages.