Although they are top scorers in the Premier League with 51 goals from the opening 22 matches, Jurgen Klopp's men have scored just six times in their last seven fixtures coming into this vital clash.
With just two league goals to his name all season, now would be the perfect time to shine for Daniel Sturridge, who is available at 5/1 (6.00) with bet365 to open the scoring against his former club and 13/8 (2.63) to strike anytime.
After finding the net for the first time in 11 games in Saturday's 2-1 FA Cup defeat against Wolves, Divock Origi can also be backed at 13/8 (2.63) to provide some much-needed firepower against the division's most miserly defence.
That pair have struggled for game time due to Klopp's for Roberto Firmino in attack, making the 25-year-old probably a more appealing prospect at 2/1 (3.00) to add to his eight league goals for the campaign.
Considering his team’s lack of form in front of goal, the German manager will be hoping that Sadio Mane 11/5 (3.20) is ready to get straight back into the action after returning from the Africa Cup of Nations.
At the other end of the pitch, Antonio Conte is having no such dilemmas thanks to an attack spearheaded by joint 15-goal top-scorer Diego Costa.
Having hit the back of the net in September's reverse fixture between the teams, the Spain international offers solid value at 4/1 (5.00) to break the deadlock, and even more so at 13/10 (2.30) anytime.
First goalscorer punters should note that bet365 offer unlimited places on this market, a concession well worth considering prior to placing your wagers on an each-way basis. E.g. If you backed Costa each-way to score first and he struck at any time in the match, you'd be paid out on the place half of the wager, unlike other firms which limit the number of places they will pay out on.
On the scoresheet four times in previous encounters with the Reds himself, Eden Hazard can be backed at 13/5 (3.60) to reach double figures for the league season firing once again here.
Meanwhile, Pedro could prove a rewarding longer shot at 3/1 (4.00) considering his threat on the counter-attack against a susceptible home backline, with Willian also a potentially lucrative 3/1 (4.00) bet for the same reason.