Top of the league less than a month ago, the Nerazzurri are now seven points adrift of leaders Napoli after taking just two points from the last available 12.
However, having run out 3-0 winners when the sides met in last August's reverse fixture, they are available at 13/8 (2.63) with Betfair Sportsbook to get back on track with a victory in Florence.
On the other hand, Stefano Pioli's men have won each of the last three home games against this opposition, and are on offer at 9/5 (2.80) to compound their misery by making it four in a row here.
None of the last 11 encounters between this pair have resulted in draws, but you can get odds of 23/10 (3.30) on them cancelling each other out in this one.
While Pioli has a full squad to choose from, opposite number Luciano Spalletti is once again without injured defenders Joao Miranda and Danilo D'Ambrosio.
Despite those absentees, the former Roma boss is unlikely to be too concerned by defensive issues, with his side having kept five clean sheets after 90 minutes in the last seven matches.
Instead, the problems lie at the other end of the pitch, where Inter have only found the net once in the previous six fixtures - a run that has included a blank against third tier Pordenone in the Coppa Italia.
Having conceded just three goals in their last seven league games and kept four clean sheets in the most recent five, Fiorentina will certainly back themselves to submit their guests to more frustration in this clash.
Tips and Predictions
Considering the hosts have only struck seven times in the previous seven league fixtures themselves, odds of 5/6 (1.83) look generous on them ensuring under 2.5 goals are scored for their seventh match in eight, as well as a sixth in seven for Inter.