Copenhagen were unbeaten in the group stages at home and did not concede a goal in their three games at Parken Stadium.
Diego Godin should be back available for selection after losing three teeth against Valencia two weeks ago.
Otherwise Simeone has no injury concerns, although he may chose to rest some players ahead of Sunday's league game with Athletic Bilbao.
Copenhagen also have an injury-free squad.
Goals at a premium in Denmark
In the last few weeks, Atletico have reverted to type and three of their last five La Liga games have been won by a 1-0 scoreline.
Los Rojiblancos have been grinding out victories without playing in particularly impressive fashion and away from home in Europe, they certainly know how to keep things tight.
Seven of their last nine away matches in Europe have seen under 2.5 goals and a repeat is priced at 5/9 (1.45).
Copenhagen part have also been pretty solid in Europe, with four of their six games in the tournament seeing less than three goals scored.
Tips and predictions
The smart money should be going on Atleti to win a low scoring game. The price of 33/20 (2.65) for an away win and under 2.5 goals appeals, while more cautious punters might back an away win and under 3.5 goals at 4/5 (1.80).Atletico Madrid to win and under 2.5 goals at 33/20 (2.65) for a 1.5pt stake with SportPesa