The Pharaohs are set to play as guests to the Black Stars on the last matchday.
Four points clear of second-placed Uganda, the North Africans have nothing to lose as a defeat will not alter their status as winners of the group.
“We succeeded in giving Egypt its spine back," Cuper told ON Sport.
"We face Ghana in the next international break and we have a friendly match.
"It is possible to include players that don’t play regularly and to fit them in our system while maintaining the balance between them as we try players in different roles.
“We want to reach the second stage in the World Cup. Everything is possible especially after what happened in the Camp Nou in 1999.”
Egypt beat Congo 2-1 on Sunday to claim their first World Cup ticket since 1990.
But for the latest turn of events, November's showdown was sure to be a clash of wild interest.
On Egypt's last visit to Ghana - in 2014 World Cup qualifying in 2013 - the Pharaohs were at sixes and sevens, heavily falling 6-1 to the Black Stars in Kumasi.