La Albirroja have collected two points from their opening two matches, meaning victory at the Arena Fonte Nova would see them safely through in second place.
Having run out 2-1 winners in the most recent encounter between these sides, they are available at 7/4 (2.75) with SportPesa to make it through to the quarter-finals with another victory here.
Already sure of first place after winning both of their first two matches, Carlos Queiroz's men are 8/5 (2.60) favourites to maintain their 100 per cent record by coming out on top.
None of the last 11 meetings between this pair have resulted in draws, but you can get odds of 9/4 (3.25) on this one finishing up all square.
With top spot already wrapped up and no injuries to contend with, Queiroz may be tempted to rotate his line-up in order to give players a rest ahead of the quarter-finals.
Richard Sanchez will be hoping to retain his place in Eduardo Berizzo’s side after finding the net on his first competitive international start in the 1-1 draw with Argentina last time out.
Despite claiming six points from six so far, Los Cafeteros have only been ahead for a combined total of 23 minutes of normal time over the course of their two fixtures.
Indeed, Duvan Zapata has scored both of his goals in the 86th minute against Argentina and Qatar, developing a reputation for providing late action after he opened his senior international account in injury time versus Peru in the final warm-up friendly match.
Considering Paraguay have seen a goal scored in the last 15 minutes of nine of their previous 13 fixtures, odds of 23/20 (2.15) look like solid value on either team finding the net from the 76th minute onwards for their third successive meeting with Colombia.